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Romana Höftberger
Assoc.Prof.Priv.-Doz.Dr. Romana Höftberger

Division of Neuropathology and Neurochemistry (Department of Neurology)
Position: Assistant Professor

Location: Medical University of Vienna
Phone: +43 1 004314040055040
E-Mail: romana.hoeftberger@meduniwien.ac.at

Further Information

Research Area

Neuroimmunology

Research Interests

Autoimmune Diseases

Principle Investigator(s)

  • Hoeftberger, Romana (Head)
  • Sachs, Gabriele
  • Abstract

    Our research is at the intersection of neuropathology and neurobiology with main focus on characterizing autoimmune diseases targeting central (CNS) and peripheral nervous system (PNS) proteins. This includes the description of neuropathology of autoimmune-mediated diseases, search for novel target antigens and associated syndromes, and development and improvement of diagnostic tests. Our research focuses on elucidating the mechanisms underlying immune-mediated tissue injury in demyelinating CNS diseases (MS, NMO, ADEM), anti-neuronal autoimmune encephalitis, PNS diseases (GBS, CIDP) and myasthenia gravis. Our findings impact multiple clinical and basic research disciplines, linking immunological processes with disease aspects in neurodegeneration, muscle diseases, and epilepsy.

    Techniques

    Our techniques comprise immunohistochemistry on frozen and paraffin embedded material, immunofluorescence including double immunofluorescence labelling, confocal laser scanning microscopy, western blot, ELISA, immunoprecipitation, and cell culture including primary neuronal and glial cell cultures 

    Selected publications

    1. Höftberger R, Lassmann H (2017) Immune-mediated disorders. In: , Handbook of Clinical Neurology : 285-299
    2. Gelpi E, Höftberger R, Graus F, Ling H, Holton J, Dawson T, Popovic M, Pretnar-Oblak J, Högl B, Schmutzhard E, Poewe W, Ricken G, Santamaria J, Dalmau J, Budka H, Revesz T, Kovacs G (2016) Neuropathological criteria of anti-IgLON5-related tauopathy Acta Neuropathol, 132 (4): 531-543
    3. Höftberger R (2015) Neuroimmunology: An Expanding Frontier in Autoimmunity Front Immunol, 6
    4. Titulaer M, Höftberger R, Iizuka T, Leypoldt F, McCracken L, Cellucci T, Benson L, Shu H, Irioka T, Hirano M, Singh G, Cobo Calvo A, Kaida K, Morales P, Wirtz P, Yamamoto T, Reindl M, Rosenfeld M, Graus F, Saiz A, Dalmau J (2014) Overlapping demyelinating syndromes and anti-N-methyl-D-aspartate receptor encephalitis Ann Neurol, 75 (3): 411-428
    5. Hoftberger R, Titulaer M, Sabater L, Dome B, Rozsas A, Hegedus B, Hoda M, Laszlo V, Ankersmit H, Harms L, Boyero S, de Felipe A, Saiz A, Dalmau J, Graus F (2013) Encephalitis and GABAB receptor antibodies: Novel findings in a new case series of 20 patients Neurology, 81 (17): 1500-1506

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