Department of Neurophysiology and Neuropharmacology (Center for Physiology and Pharmacology)
Position: Associate Professor
E-Mail: karlheinz.hilber@meduniwien.ac.at
Research Area
Cardiac Electrophysiology, Ion Channels, Muscular Dystrophies
Abstract
We study ion channel and Ca handling abnormalities in the dystrophic heart and try to identify pathophysiological mechanisms as well as new treatment strategies. In addition, the effects of drugs on cardiac ion channels are focus of our research.
Techniques
patch clamp techniques, isolation of myocytes from neonatal and adult mouse and guinea pig hearts, muscular dystrophy mouse models, standard biochemistry and molecular biology. Members of this research group have access to a cell culture, a standard biochemistry and molecular biology lab, and patch clamp rigs.
Selected publications
- Szabó P, Ebner J, Koenig X, Hamza O, Watzinger S, Trojanek S, Abraham D, Todt H, Kubista H, Schicker K, Remy S, Anegon I, Kiss A, Podesser B, Hilber K (2021) Cardiovascular phenotype of the Dmdmdx rat – a suitable animal model for Duchenne muscular dystrophy Dis. Model. Mech, 14 (2)
- Koenig X, Kovar M, Boehm S, Sandtner W, Hilber K (2012) Anti-addiction drug ibogaine inhibits hERG channels: a cardiac arrhythmia risk Addict Biol, 19 (2): 237-239
| Weblink | - Koenig X, Dysek S, Kimbacher S, Mike A, Cervenka R, Lukacs P, Nagl K, Dang X, Todt H, Bittner R, Hilber K (2011) Voltage-Gated Ion Channel Dysfunction Precedes Cardiomyopathy Development in the Dystrophic Heart PLoS One, 6 (5): e20300