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Scholze, Petra
Scholze, Petra

Department: Division of Pathobiology of the Nervous System
Head: Scholze, Petra, Assoc.Prof. Priv.Doz. Mag. Dr.

Research Area

Cysteine Loop Ligand-Gated Ion Channels: GABAA Receptors and Nicotinic Acetylcholine Receptors

Description

Both GABA-A and nicotinic Acetylcholine Receptors (nAChRs) are of pentameric structure, where 5 out of a set of 19 (GABA-A) or 17 (nAChR) subunits assemble to form different receptors subtypes. The functional properties of these subtypes are primarily determined by their subunit composition, and knowledge of the molecular structure is thus crucial for an understanding of receptor function in health and disease. Different receptor subtypes also display different drug binding sites, and the identification of subtype selective compounds is of great interest for both GABA-A and nACh receptors.

We are therefore aiming to identify receptors subtypes occuring in distinct areas in the central and peripheral nervous system. We are also study drug binding sites, trying to identify subtype selective compounds. 

 

Members

  • Huck, Sigismund, Ao.Prof. Dr., em.
  • Simeone, Xenia, Mag. Dr

    • Selected Publications of Principle Investigator

    1. Müller V, Ernst M, Baykuchkarova A, Koniuszewski F, Bampali K, Seidel T, Scholze P (2024) Probes for the heterogeneity of muscimol binding sites in rat brain Front. Pharmacol., 15: 1368527
    2. Görgülü I, Jagannath V, Pons S, Koniuszewski F, Groszer M, Maskos U, Huck S, Scholze P (2024) The human‐specific nicotinic receptor subunit CHRFAM7A reduces α7 receptor function in human induced pluripotent stem cells‐derived and transgenic mouse neurons Eur J Neurosci, 60 (5): 4893-4906
    3. Simeone X, Koniuszewski F, Müllegger M, Smetka A, Steudle F, Puthenkalam R, Ernst M, Scholze P (2021) A Benzodiazepine Ligand with Improved GABAA Receptor α5-Subunit Selectivity Driven by Interactions with Loop C Mol Pharmacol, 99 (1): 39-48
    4. Scholze P, Huck S (2020) The α5 Nicotinic Acetylcholine Receptor Subunit Differentially Modulates α4β2* and α3β4* Receptors Front.Synaptic Neuroscience, 12: 18:63
    5. Elgarf A, Siebert D, Steudle F, Draxler A, Li G, Huang S, Cook J, Ernst M, Scholze P (2018) Different Benzodiazepines Bind with Distinct Binding Modes to GABAA Receptors ACS Chem Biol, 13 (8): 2033-2039