By Authors

Publications - sorted by Authors

• Herbst R, Huijbers M, Oury J, Burden S (2024) Building, Breaking, and Repairing Neuromuscular Synapses Cold Spring Harb Perspect Med., 16 (5): a041490

• Rodríguez Cruz P, Cossins J, Cheung J, Maxwell S, Jayawant S, Herbst R, Waithe D, Kornev A, Palace J, Beeson D (2020) Congenital myasthenic syndrome due to mutations in MUSK suggests that the level of MuSK phosphorylation is crucial for governing synaptic structure Hum Mut, 41 (3): 619-631

• Herbst R (2020) MuSK function during health and disease Neurosci Lett, 41 (3): 619-631

• Koneczny I, Herbst R (2019) Myasthenia Gravis: Pathogenic Effects of Autoantibodies on Neuromuscular Architecture Cells, 8 (7): 671

• Kim J, Caine C, Awano T, Herbst R, Monani U (2017) Motor neuronal repletion of the NMJ organizer, Agrin, modulates the severity of the spinal muscular atrophy disease phenotype in model mice Hum Mol Genet, Epub ahead of print
  | doi:10.1093/hmg/ddx124 |
• Dorninger F, Herbst R, Kravic B, Camurdanoglu B, Macinkovic I, Zeitler G, Forss-Petter S, Strack S, Khan M, Waterham H, Rudolf R, Hashemolhosseini S, Berger J (2017) Reduced Muscle Strength in Ether Lipid-Deficient Mice Is Accompanied by Altered Development and Function of the Neuromuscular Junction J Neurochem, 143: 569-583
  | Article (PDF) |
• Moser B, Hochreiter B, Herbst R, Schmid J (2017) Fluorescence colocalization microscopy analysis can be improved by combining object-recognition with pixel-intensity-correlation Biotechnol J, 12 (1): 1600332
  | Weblink |

• Camurdanoglu BZ, Hrovat C, Dürnberger G, Madalinski M, Mechtler K, Herbst R (2016) MuSK kinase activity is modulated by a serine phosphorylation site in the kinase loop Sci Rep, 6: 33583
  | Weblink |

• Mihailovska E, Raith M, Valencia RG, Fischer I, Banchaabouchi MA, Herbst R, Wiche G (2014) Neuromuscular synapse integrity requires linkage of acetylcholine receptors to postsynaptic intermediate filament networks via rapsyn-plectin 1f complexes Mol Cell Biol, 25 (25): 4130-4149
  | abstract |
• Duernberger G, Camurdanoglu BZ, Tomschik M, Schutzbier M, Roitinger E, Hudecz O, Mechtler K, Herbst R. (2014) Global analysis of muscle-specific kinase signaling by quantitative phosphoproteomics. Mol Cell Proteomics, 13 (8): 1993-2003
  | Weblink |

• Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Mimata H, Yoshimura A, Tamir I, Herbst R, Martinez J, Penninger JM et al. (2013) CLP1 links tRNA metabolism to progressive motor-neuron loss Nature, 495 (7442): 474-480
  | Weblink |
• Luiskandl S, Woller B, Schlauf M, Schmid JA, Herbst R (2013) Endosomal trafficking of the receptor tyrosine kinase MuSK proceeds via clathrin-dependent pathways, Arf6 and actin. FEBS J., 280(14): 3281-97
  | Weblink |
• Ben Ammar A,Soltanzadeh P,Bauché S,Richard P,Goillot E,Herbst R,Gaudon K,Huzé C,Schaeffer L,Yamanashi Y,Higuchi O,Taly A,Koenig J,Leroy JP,Hentati F,Najmabadi H,Kahrizi K,Ilkhani M,Fardeau M et al. (2013) A mutation causes MuSK reduced sensitivity to agrin and congenital myasthenia PLoS.ONE., 8: e53826
  | Weblink |

• Mazhar S., Herbst R. (2012) The formation of complex acetylcholine receptor clusters requires MuSK kinase activity and structural information from the MuSK extracellular domain Mol Cell Neurosci, 49: 475-486
  | Article (PDF) |

• Woller B., Luiskandl S., Popovic M., Prieler B.E., Ikonge G., Mutzl M., Rehmann H., Herbst R. (2011) Rin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22. BBA Mol Cell Res, 1813: 1198-1210
  | Weblink |

• Herbst R, Iskratsch T, Unger E, Bittner RE (2009) Aberrant development of neuromuscular junctions in glycosylation-defective Large-myd mice. Neuromuscul Disord., 19(5): 366-78
• Ruggiu M, Herbst R, Kim N, Jevsek M, Fak JJ, Mann MA, Fischbach G, Burden SJ, Darnell RB (2009) Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing. Proc Natl Acad Sci USA, 106: 3513-3518

• Galabova-Kovacs, G., Catalanotti, F., Matzen, D., Reyes, G.X., Zezula, J., Herbst, R., Silva, A., Walter, I. and Baccarini, M. (2008) Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal CNS development. JCB, 180: 957-971

• Nishynska, V., Neumüller, R. and Herbst, R (2007) Phosphpinositide 3-kinase acts through the small GTPases Rac and Cdc42 during agrin-induced acetylcholine receptor clustering. Dev. Neurobiology, 67: 1047-1058

• Chevessier F., Faraut B., Ravel-Chapuis A., Richard P., Gaudon K., Bauche S., Prioleau C., Herbst R., Goillot E., Ioos C., Azulay J.P., Attarian S., Leroy J.P., Fournier E., Legay C., Schaeffer L., Ko (2005) Towards the molecular elucidation of congenital myasthenic syndromes: identification of mutations in MuSK. Acta Myol, 24: 55-59

• Chevessier, F., Faraut, B., Ravel-Chapuis, A., Richard, P., Gaudon, K., Bauche, S., Prioleau, C., Herbst, R., Goillot, E., Ioos, C., Azulay, J.P., Attarain, S., Leroy, J.P., Fournier, E., et al. (2004) MuSK, a new target for mutations causing congenital myasthenic syndrome. Hum Mol Genet, 13: 3229-3240

• Herbst, R., Avetisova, E. and Burden, S.J. (2002) Restoration of synapse formation in MuSK mutant mice expressing a MuSK/Trk chimeric receptor. Development, 129: 5449-5460

• Herbst R. (2002) Agrin/MuSK signaling: molecular aspects of neuromuscular synapse formation. Neuroforum, 2/02: 187-192

• Barton, J.L., Herbst, R., Bosisio, D., Higgins, L. and Nicklin, M.J.H. (2000) A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities. Eur. J. Immunol., 30: 3299-3308
• Herbst, R. and Burden, S.J. (2000) The juxtamembrane region of MuSK has a critical role in agrin-mediated signaling. EMBO J., 19: 67-77

• Herbst, R., Barton, J.L. and Nicklin, M.J. (1997) A mammalian homolog of the bacterial monomeric sarcosine oxidases maps to mouse chromosome 11, close to Cryba1. Genomics, 46: 480-482
• Herbst, R. and Nicklin, M.J. (1997) SEZ-6: promoter selectivity, genomic structure and localized expression in the brain Brain Res, 44: 309-322