Department of Neurology (Department of Neurology)
Position: Doctor-in-training
E-Mail: tobias.zrzavy@meduniwien.ac.at
Research Area
Multiple Sclerosis, Neuroimmunology, Neuromyelitis Optica
Research Interests
Autoimmune Diseases of the Nervous System, Cerebrospinal Fluid, Multiple Sclerosis, Neuroimmunology, Neuromyelitis Optica
Abstract
Studying cellular and molecular mechanisms of inflammation in CNS disease with a focus on multiple sclerosis (MS), antibody-mediated autoimmune enecephalitis, neuromyelitis optica spectrum disorder (NMOSD), MOG antibody-associated disease (MOGAD).
Techniques
- Immunohistochemistry, Flow cytometry, In-depth immunophenotyping, Single-cell sequencing
- Peripheral blood, cerebrospinal fluid, CNS tissue
Selected publications
- Zrzavy T, Schwaiger C, Wimmer I, Berger T, Bauer J, Butovsky O, Schwab J, Lassmann H, Höftberger R (2021) Acute and non-resolving inflammation associate with oxidative injury after human spinal cord injury Brain, 144(1): 144-161
- Zrzavy T, Endmayr V, Bauer J, Macher S, Mossaheb N, Schwaiger C, Ricken G, Winklehner M, Glatter S, Breu M, Wimmer I, Kovacs G, Risser D, Klupp N, Simonitsch‐Klupp I, Roetzer T, Rommer P, Berger T, Gelpi E, Lassmann H, Graus F, Dalmau J, Höftberger R (2021) Neuropathological variability within a spectrum of NMDAR‐encephalitis. Ann Neurol, : 2021 Sep 25. doi: 10.1002/ana.26223. Online ahead of print.
- Zrzavy T, Machado-Santos J, Christine S, Baumgartner C, Weiner H, Butovsky O, Lassmann H (2018) Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts Brain Pathol, 28(6): 791-805
- Zrzavy T, Hametner S, Wimmer I, Butovsky O, Weiner H, Lassmann H (2017) Loss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis Brain, 140 (7): 1900-1913
- Haider L, Zrzavy T, Hametner S, Höftberger R, Bagnato F, Grabner G, Trattnig S, Pfeifenbring S, Brück W, Lassmann H (2016) The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain Brain, 139 (3): 807-815