Department: Division of Neuroimmunology
Head: Bauer, Jan, Ao.Univ.Prof. Dr.
Research Area
Inflammation in the CNS
Description
Research at the Department of Neuroimmunology focuses on pathological mechanisms of inflammatory diseases of the nervous system. In this large area of research, my special interests are the inflammatory reactions in epileptic disorders. Degeneration in epileptic brain can result from cytotoxicity by cytotoxic T cells, pathogenic antibodies with or without associated complement activation. In addition immune-mediatory or cytotoxic factors from the innate immune system can regulate or enhance the neurodegeneration and epileptic seizures. Neuropathological analysis of epileptic brains can be used to reveal which inflammatory reactions are occurring during ideases. One of these diseases studied is Rasmussen encephalitis, an epileptic disorder of unknown etiology mostly found in children. These pathological studies of Rasmussen encephalitis, antibody-associated encephalitides and other forms of epilepsy are performed in close cooperation with Prof. Dr. Christian Bien from the Epilepsy Centre of the Hospital Mara in Bielefeld, Germany. This work is complemented by the study of inflammatory reactions in other human diseases such as Multiple Sclerosis and various virus encephalitides (for instance progressive multifocal leukoencephalitis ). Besides the analysis of human brain, the study of various animal models of autoimmune or virus induced inflammatory CNS disease may give new insights in the initiation and development of CNS inflammation. These studies are performed in long-term collaboration with the research groups of Prof. Dr. Roland Liblau (Purpan University Hospital) in Toulouse, France and Prof. Dr. Bert ´t Hart (BPRC) in Rijswijk, The Netherlands.
Members
Selected Publications of Principle Investigator
- Gross C, Meyer C, Bhatia U, Yshii L, Kleffner I, Bauer J, Tröscher A, Schulte-Mecklenbeck A, Herich S, Schneider-Hohendorf T, Plate H, Kuhlmann T, Schwaninger M, Brück W, Pawlitzki M, Laplaud D, Loussouarn D, Parratt J, Barnett M, Buckland M, Hardy T, Reddel S, Ringelstein M, Dörr J, Wildemann B, Kraemer M, Lassmann H, Höftberger R, Beltrán E, Dornmair K, Schwab N, Klotz L, Meuth S, Martin-Blondel G, Wiendl H, Liblau R (2019) CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome Nat Commun, 10 (1): 5779
- Tröscher A, Wimmer I, Quemada-Garrido L, Köck U, Gessl D, Verberk S, Martin B, Lassmann H, Bien C, Bauer J (2019) Microglial nodules provide the environment for pathogenic T cells in human encephalitis Acta Neuropathol, 137(4): 137(4):619-635
- Wimmer I, Tröscher A, Brunner F, Rubino S, Bien C, Weiner H, Lassmann H, Bauer J (2018) Systematic evaluation of RNA quality, microarray data reliability and pathway analysis in fresh, fresh frozen and formalin-fixed paraffin-embedded tissue samples Sci Rep, 8 (1): 6351
| Weblink | - Laukoter S, Rauschka H, Tröscher A, Köck U, Saji E, Jellinger K, Lassmann H, Bauer J (2017) Differences in T cell cytotoxicity and cell death mechanisms between progressive multifocal leukoencephalopathy, herpes simplex virus encephalitis and cytomegalovirus encephalitis Acta Neuropathol, 133(4): 613-627
- Bauer J, Gold R, Adams O, Lassmann H. (2015) Progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome (IRIS) Acta Neuropathol, 130(6): 751-764