Department: Division of Pathobiology of the Nervous System
Head: Scholze, Petra, Assoc.Prof. Priv.Doz. Mag. Dr.
Research Area
Cysteine Loop Ligand-Gated Ion Channels: GABAA Receptors and Nicotinic Acetylcholine Receptors
Description
Both GABA-A and nicotinic Acetylcholine Receptors (nAChRs) are of pentameric structure, where 5 out of a set of 19 (GABA-A) or 17 (nAChR) subunits assemble to form different receptors subtypes. The functional properties of these subtypes are primarily determined by their subunit composition, and knowledge of the molecular structure is thus crucial for an understanding of receptor function in health and disease. Different receptor subtypes also display different drug binding sites, and the identification of subtype selective compounds is of great interest for both GABA-A and nACh receptors.
We are therefore aiming to identify receptors subtypes occuring in distinct areas in the central and peripheral nervous system. We are also study drug binding sites, trying to identify subtype selective compounds.
Selected Publications of Principle Investigator
- Beiranvand F, Zlabinger C, Orr-Urtreger A, Ristl R, Huck S, Scholze P (2014) Nicotinic acetylcholine receptors control acetylcholine and noradrenaline release in the rodent habenulo-interpeduncular complex Br J Pharmacol, 171 (23): 5209-5224
| Article (PDF) | - Scholze P, Koth G, Orr-Urtreger A, Huck S (2012) Subunit composition of α5-containing nicotinic receptors in the rodent habenula J Neurochem, 121(4): 551-560
| Article (PDF) | - Scholze P, Ciuraszkiewicz A, Grössl F, Orr-Urtreger A, McIntosh JM, Huck S (2011) Alpha4beta2 Nicotinic Acetylcholine Receptors n the Early Postnatal Mouse Superior Cervical Ganglion Dev. Neurobiology, 71 (5): 390-399
| Article (PDF) | - David R, Ciuraszkiewicz A, Simeone X, Orr-Urtreger A, Papke RL, McIntosh JM, Huck S, Scholze P (2010) Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes Eur J Neurosci, 6: 978-993
| Article (PDF): 1 2 | - Scholze P., Orr-Urtreger A., Changeux J.-P., McIntosh J.M. , Huck S (2007) Catecholamine outflow from mouse and rat brain slice preparations evoked by nicotinic acetylcholine receptor activation and electrical field stimulation Br J Pharmacol, 151: 414-422
| Article (PDF) |