Department: Division of Neuroimmunology
Head: Lassmann, Hans, O.Univ.Prof. Dr.med.univ. Dr.h.c.
Research Area
Neuroimmunology, Brain Inflammation, Multiple Sclerosis
Description
Our main research interests are focused on basic mechanisms of immune surveillance of the nervous system and the pathogenetic mechanisms, driving inflammation and immune mediated tissue injury in the central and peripheral nervous system. Basic mechanisms are investigated in experimental models of inflammatory brain disease, in particular in experimental autoimmune encephalomyelitis. A major focus, however, is devoted to research, directly studying the mechanisms and consequences of brain inflammation in human diseases, such as multiple sclerosis, neuromyelitis optica and other autoimmune diseases of the nervous system. In our laboratory we specially focus on techniques of molecular pathology and immunopathology, including general neuropathology, immunocytochemistry, confocal laser microscopy and electron microscopy, as well as gene expression analysis in micro-dissected tissue lesions. In cooperation with partners in the fields of clinical neurology and neuroimaging we are also interested in the translation of the respective results for improved diagnostics and therapy. Our research is continuously funded by grants from the Austrian Science Foundation, the European Union and from Charities.
Selected Publications:
1. Fischer MT, Wimmer I, Höftberger R, Gerlach S, Haider L, Zrzavy T, Hametner S, Mahad D, Binder CJ, Krumbholz M, Bauer J, Bradl M, Lassmann H. (2013) Disease-specific molecular events in cortical multiple sclerosis lesions Brain, 136(Pt 6): 1799-1815
2. Hametner S, Wimmer I, Haider L, Pfeifenbring S, Brück W, Lassmann H. (2013) Iron and Neurodegeneration in the Multiple Sclerosis Brain Ann Neurol, 74: 848–861
3. Fischer MT, Sharma R, Lim J, Haider L, Frischer J, Drexhage J, Mahad D, Bradl M, van Horssen J, Lassmann H (2012) NADPH Oxidase Expression in Active Multiple Sclerosis Lesions in Relation to Oxidative Tissue Damage and Mitochondrial Injury Brain, 135: 886-899
4. Lassmann H, van Horssen J, Mahad D (2012) Progressive multiple sclerosis: pathology and pathogenesis Nat Rev Neurol, 8(11): 647-656
Selected Publications of Principle Investigator
- Mahad DH, Trapp BD, Lassmann H (2015) Pathological mechanisms in progressive multiple sclerosis Lancet Neurology, 14: 183–93
- Fischer MT, Wimmer I, Höftberger R, Gerlach S, Haider L, Zrzavy T, Hametner S, Mahad D, Binder CJ, Krumbholz M, Bauer J, Bradl M, Lassmann H. (2013) Disease-specific molecular events in cortical multiple sclerosis lesions Brain, 136(Pt 6): 1799-1815
| Weblink | - Hametner S, Wimmer I, Haider L, Pfeifenbring S, Brück W, Lassmann H. (2013) Iron and Neurodegeneration in the Multiple Sclerosis Brain Ann Neurol, 74: 848–861
- Fischer MT, Sharma R, Lim J, Haider L, Frischer J, Drexhage J, Mahad D, Bradl M, van Horssen J, Lassmann H (2012) NADPH Oxidase Expression in Active Multiple Sclerosis Lesions in Relation to Oxidative Tissue Damage and Mitochondrial Injury Brain, 135: 886-899
| Article (PDF) | - Lassmann H, van Horssen J, Mahad D (2012) Progressive multiple sclerosis: pathology and pathogenesis Nat Rev Neurol, 8(11): 647-656